Child assent is recommended in addition to parental consent when enrolling children in clinical research; however, appreciation and relevance ascribed to these concepts vary in different contexts, and information on attitudes towards storage of biological samples for future research is limited, especially in developing countries. We assessed caregivers’ understanding and appreciation of consent and assent procedures, and their attitudes towards use of stored blood samples for future research prior to enrolling a child in clinical research. A total of 17 in-depth (...) interviews were conducted with primary caregivers of children at enrolment or on the immediate follow-up date. All caregivers recalled significant amount information from the study information sheet and were able to appropriately link such information to the consent process. While all participants confirmed information received prior to blood sampling as adequate, a few noted that the purpose was not sufficiently well communicated. Caregivers felt children were cognitively vulnerable, and prone to decisions that were not necessarily in their best interest. Nearly all caregivers felt it was their right and responsibility to overrule objections from their ward’s regarding enrolment into specific study or receipt of a therapeutic procedure. There were no objections or concerns regarding use of stored biological samples for future research purposes. There is thus, a need to improve understanding of caregivers on the information provided during the informed consent process. Context-specific studies on the age of assent in specific populations are needed. (shrink)

Review of Paul Pietroski, Causing Actions.

What drives much of the current philosophical interest in the idea of group cognition is its appeal to the manifestation of psychological properties—understood broadly to include states, processes, and dispositions—that are in some important yet elusive sense emergent with respect to the minds of individual group members. Our goal in this paper is to address a set of related, conditional questions: If human mentality is real yet emergent in a modest metaphysical sense only, then: (i) What would it mean for (...) a group to have emergent cognitive states? (ii) Is this even a metaphysically coherent view? (iii) Relative to which notion of emergence do we have reason to believe that certain groups in fact have emergent cognitive states? We shall argue that evidence from a wide variety of social science domains makes it plausible that there are group cognitive states and processes no less metaphysically emergent than human cognitive (and other special science) states and processes. (shrink)

The motivation for this study originated from a review of literature which led the current researcher to the realisation that not much critical study has been performed on the theology and practice of Bible inspiration and its authority in Christ Apostolic Church. This article set out to identify the tenet of faith of the church on inspiration and authority of the Scriptures, locate this tenet in the context of Evangelical theology and compare the initial understanding of the concept of Bible (...) inspiration in CAC with the way it is perceived by the church members today. Primary sources of data for the work comprised the Bible, editions of CAC constitution and structured interviews. Secondary sources of data comprised Bible commentaries, books, journal articles and the Internet. Data collected were analysed using Conservative Evangelical theological framework. The study discovered that CAC held to word-for-word inerrancy of the Scriptures, even of its vernacular translations, and its binding authority on Christians in all areas of their lives. The study revealed that the belief of CAC on Bible inspiration and its authority located CAC at the centre of Evangelical theology which researchers have identified as inerrancy. Finally, the study discovered that the initial position of CAC on the inspiration and authority of the Bible remained the same as held by contemporary members of the church. The work provides theological relevance for the study of one of the doctrines of Pentecostalism in Nigeria. (shrink)

John Riley 'A (Ukrainian) Life in Soviet Film: Liber's _Alexander Dovzhenko_' _Film-Philosophy_, vol. 7 no. 31, September 2003.

The book includes contributions by Sarah-Jayne Blakemore, George F. R. Ellis, Christopher D. Frith, Mark Hallett, David Hodgson, Owen D. Jones, Alicia Juarrero, J. A. Scott Kelso, Christof Koch, Hans Küng, Hakwan C. Lau, Dean Mobbs,...

This article address the issue of employee safety and the social responsibility of multinational apparel retailers who contract with Bangladesh manufacturers in their global supply chain. Both the Alliance for Bangladesh Worker Safety and the Accord on Fire and Building Safety in Bangladesh have been identified as the two primary facilitators for global apparel industry efforts to actively address this serious human rights issue; thus, they have the potential to help drive the success of the industry's corporate citizenship efforts to (...) successfully manage the issue of fire and building safety in Bangladesh. The article further explores these relationships within the context of the “global corporate citizenship” concept, and develops a rationale for the limits of a socially responsible supply chain. In the context of global corporate citizenship, the article describes the existing state of these two industry organizations remediation efforts to ensure a stable supply chain in Bangladesh, and offers an analysis of existing industry nonmarket strategy approaches to improving contractor's factory fire and building safety environments for their employees. Lastly, a comprehensive set of nonmarket strategies for multinational apparel retailers is recommended when addressing their global corporate citizenship commitments to a safe working environment for Bangladesh garment manufacturing employees. (shrink)

Introduction: Probationers, offenders with less serious and non-violent offences, and under statutory supervision, have low levels of self-esteem and physical health, and high level of family conflict, and poorer quality of family relationships. This study examined the effectiveness of the existing probation service and the additional use of a positive family holistic health intervention to enhance physical, psychological, and family well-being in probationers and relationships with probation officers.Methods: Probationers under the care of the Hong Kong Social Welfare Department were randomized (...) into a care-as-usual control group, a brief intervention group receiving two 1-h individual sessions [of a brief theory-based positive family holistic health intervention integrating Zero-time Exercise and positive psychology themes of “Praise and Gratitude” in the existing probation service], or a combined intervention group receiving BI and a 1-day group activity with family members. The outcomes were physical activity, fitness performance, self-esteem, happiness, anxiety and depression symptoms, life satisfaction, quality of life, family communication and well-being, and relationships with probation officers. Self-administered questionnaires and simple fitness tests were used at baseline, 1-month and 3-month follow-up. Linear mixed model analysis was used to compare difference in the changes of outcome variables among groups, adjusted of sex, age, and baseline values. Focus group interviews were conducted. Thematic content analysis was used.Results: 318 probationers were randomized into CAU, BI, or CI group. CAU showed enhanced physical activity, fitness performance and psychological health, and family communication with small effect sizes. BI and CI showed further improved physical activity, family communication and family well-being. Additionally, CI reported greater improvements in the relationships with probation officers than CAU with a small effect size. CI also reported greater increases in physical activity and family communication than BI with small to moderate effect sizes. Qualitative feedbacks corroborated the quantitative findings.Conclusion: Our trial provided the first evidence of the effectiveness of probation service and the additional use of an innovative, relatively low-cost, theory-based brief positive family holistic health intervention. This intervention may offer a new model for enhancing probation service.Trial Registration: The research protocol was registered at the National Institutes of Health. (shrink)

Steroid hormone receptors are ligand‐inducible transcription factors that exhibit potent effects on gene expression in living cells. Precise dissection of their mode of action at the molecular level can best be carried out in functional cell‐free systems. This article will describe the benefits of such systems and review their development up to the recent establishment of steroid receptor‐dependent in vitro transcription. Subsequent advances in our knowledge of receptor function arising from the exploitation of this powerful experimental tool will be described. (...) Particular emphasis will be placed upon two key problems: the role of steroid hormone in receptor action and the mechanisms by which steroid receptors activate gene transcription. (shrink)

Opposition: Obedience and authority in Exodus 32-34 / George W. Coats -- The theological significance of contradiction within the Book of the Covenant / Paul D. Hanson -- The renewed authority of Old Testament wisdom for contemporary faith / Wayne Sibley Towner -- A stylistic study of the priestly creation story / Bernhard W. Anderson -- "I will not cause it to return" in Amos 1 and 2 / Rolf P. Knierim.

A Constituição Brasileira de 1988, assim como boa parte das Constituições contemporâneas, abriga uma espécie normativa que a doutrina denomina Princípios Constitucionais. Até recentemente, pouca atenção era conferida às normas principiológicas, seja por parte da doutrina e da jurisprudência. Hoje, são elas alvo de acirrados debates no meio acadêmico, mais precisamente no que concerne ao seu grau de eficária e concretização. Os autores trazem, aqui, subsídios para a discussão, procurando encontrar instrumentos e mecanismos aptos a concretizá-los em sua plenitude.

PurposeTo use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD).MethodsA vocabulary was acquired from four AMD experts who examined 100 ophthalmoscopic images. The vocabulary was analyzed, hierarchically structured, and incorporated into a collaborative computer classification system called IDOCS. Using this system, three of the experts examined images from a second set of digital images compiled from more than 1000 patients with AMD. Images (...) were annotated, and features were identified and defined. Decision trees, a machine learning method, were trained on the data collected and used to extract patterns. Interrelationships between the data from the different clinicians were investigated.ResultsSix drusen classes in the structured vocabulary were largely sufficient to describe all the identified features. The decision trees classified the data with 76.86% to 88.5% accuracy and distilled patterns in the form of hierarchical trees composed of 5 to 15 nodes. Experts were largely consistent in their characterization of soft, and to a lesser extent, hard drusen, but diverge in definition of other drusen. Size and crystalline morphology were the main determinants of drusen type across all experts.ConclusionsMachine learning is a powerful tool for the characterization of disease phenotypes. The creation of a defined feature set for AMD will facilitate the development of an IDOCS-based classification system. (shrink)

We have conducted an experimental study of V-type electromagnetically induced transparency in sodium. Its principles are elucidated by a simple model. Measurements show decreased fluorescence and absorption depending on the detuning of the driving and probe fields, which is in agreement with the results of numerical simulation.

The structure of people’s conceptual knowledge of concrete nouns has traditionally been viewed as hierarchical (Collins & Quillian, 1969). For example, superordinate concepts (vegetable) are assumed to reside at a higher level than basic‐level concepts (carrot). A feature‐based attractor network with a single layer of semantic features developed representations of both basic‐level and superordinate concepts. No hierarchical structure was built into the network. In Experiment and Simulation 1, the graded structure of categories (typicality ratings) is accounted for by the flat (...) attractor network. Experiment and Simulation 2 show that, as with basic‐level concepts, such a network predicts feature verification latencies for superordinate concepts (vegetable ). In Experiment and Simulation 3, counterintuitive results regarding the temporal dynamics of similarity in semantic priming are explained by the model. By treating both types of concepts the same in terms of representation, learning, and computations, the model provides new insights into semantic memory. (shrink)

“Why is there something rather than nothing?” This is perhaps one of the most annoying questions posed in recent times by and to philosophers. It has troubled at least two major thinkers in the last and in this century, namely the romantic idealist Friedrich Schelling and the contemporary existentialist Martin Heidegger, since it was first formulated by Leibniz. We can easily get rid of the question as being simplistic; since although it may be true that nothing is simpler than something, (...) we have no notion of what the simplicity of nothing might consist in. Or we can say that the question is related to the theological answer of a benevolent creator, and hence is not able even to be asked within the ambient of the finite human understanding. Or we may say that the question is supremely hypothetical, in that it would presuppose what is not, in fact, the case; and philosophy can be concerned only with what is. Furthermore, to ask the question in any genuine fashion, the nonexistence of the questioner would seem to be required. The question, therefore, appears Zen-like: “What is the answer to a question posed by a nonexistent questioner?”. (shrink)

This is a qualitative study of the relationship between consonant cluster articulation and intelligibility in English as a Lingua Franca interactions in Japan. Some research has claimed that the full articulation of consonant clusters in lexeme-initial and lexeme-medial position is critical to the maintenance of intelligibility. Using conversation analytic methodology to examine a corpus of repair sequences in interactions among English as a Lingua Franca speakers at a Japanese university, this study claims that consonant elision in consonant clusters in lexeme-initial, (...) lexeme-medial, and lexeme-final position can attenuate intelligibility, and that the insertion of an elided consonant into a word that was oriented to as unintelligible can help restore intelligibility in English as a Lingua Franca. (shrink)

More than 50 years after the publication of the Harvard Committee Report that sought to define death according to whole-brain function criteria, this document continues to generate a diversity of o...

Skeletal myoblasts have their origin early in embryogenesis within specific somites. Determined myoblasts are committed to a myogenic fate; however, they only differentiate and express a muscle‐specific phenotype after they have received the appropriate environmental signals. Once proliferating myoblasts enter the differentiation programme they withdraw from the cell cycle and form post‐mitotic multinucleated myofibres (myogenesis); this transformation is accompanied by muscle‐specific gene expression. Muscle development is associated with complex and diverse protein isoform transitions, generated by differential gene expression and mRNA (...) splicing. The myofibres are in a state of dynamic adaptation in response to hormones, mechanical activity and motor innervation, which modulate differential gene expression and splicing during this functional acclimatisation. This review will focus on the profound effects of thyroid hormone on skeletal muscle, which produce alterations in gene and isoform expression, biochemical properties and morphological features that precipitate in modified contractile/mechanical characteristics. Insight into the molecular events that control these events was provided by the recent characterisation of the MyoD gene family, which encodes helix‐loop‐helix proteins; these activate muscle‐specific transcription and serve as targets for a variety of physiological stimuli. The current hypothesis on hormonal regulation of myogenesis is that thyroid hormones (1) directly regulate the myoD and contractile protein gene families, and (2) induce thyroid hormone receptor‐transcription factor interactions critical to gene expression. (shrink)

Beginning with the publication of Kant’s _Critique of Pure Reason_ and extending through to Hegel’s death, the period known as German Idealism signaled the end of an epoch of rationalism, empiricism, and enlightenment—and the beginning of a new “critical” period of philosophy. The most comprehensive anthology of this vital tradition to date, _German Idealism_ brings together an expansive selection of readings from the tradition’s major figures like Kant, Hegel, Fichte, and Schelling. Arranged thematically into sections on topics such as the (...) relationships between self and knowledge, freedom and morality, law and state, and nature and science, to name a few, _German Idealism_ discloses many of the contrasts that helped to differentiate each of the tradition’s key thinkers. Each expertly translated text comes with an editorial introduction to guide readers through many of the problems the texts specifically deal with, as well as their historical context. The most accessible and expansive introduction to German Idealism ever, this anthology will be hailed by instructors and scholars as the most dependable guide to the tradition for years to come. (shrink)

One of the foremost contributions to the study of the history of ideas. Examines ancient sources pertaining to the original condition of mankind.